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The Sedative and Anxiolytic Activities of Cedrol and Virginian Cedarwood Essential Oil

Cedrol

Cedrol is a tricyclic sesquiterpene alcohol commonly occurring in the essential oils of conifer trees, especially those belonging to the Cupressus and Juniperus genera. It occurs in essential oil of Juniperus virginiana (Virginian, red or Eastern red cedarwood) (Figure 1) at proportions of approximately 24-32% (ter Heide et al, 1988; Kitchens et al, 1971). The compound presents minimal risk in terms of skin irritancy, allergenicity and toxicity (Tisserand & Young, 2014).

     Figure 1. Virginian cedarwood (Juniperus virginiana)

Cedrol has exhibited in vitro antimicrobial activity against Gram-positive bacteria and yeast, and cytotoxic activity against human lung, liver and oral cancer cells (Su et al, 2012). The compound was also shown to contribute to the potentially beneficial effects of the methanol extract of Juniperus chinenesis on Alzheimer’s disease, specifically through inhibiting the enzymes...

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